Immunoglobulins play a key role in the immune system. CDC has developed and tested hybridoma cell lines (monoclonal antibody (mAb) clones) for human IgG and other immunoglobulins. The mAbs generated from those hybridomas could be used as a reagent (second Ab) of anti-human immunoglobins in a diagnostic assay for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the virus that causes COVID-19 (coronavirus disease 2019) and other assays that detect antigen specific antibodies from human sera.
Inventor First Name:
Carol
Charlotte
Gale
Deborah
Donald
Charles
Thomas
Inventor Last Name:
Aloisio
Black
Galland
Moore
Phillips
Reimer
Wells
E Number Only:
E-138-2014
Inv Is lead:
Provider Technology ID:
3443
LPM Zip:
20892-9804
LPM Organization:
NIH Office of Technology Transfer
LPM Phone:
301-594-9719
LPM State:
MD
LPM Suffix:
J.D., M.B.A.
Publication Caption:
PMID 3899923
Publication Link:
https://pubmed.ncbi.nlm.nih.gov/3899923
- Antibody
- Vaccine
Updated On:
Tuesday, May 18, 2021
Publication Title:
Jefferis R, et al.
LPM Last Name:
Surabian
LPM FIrst Name:
Karen
Date Published:
Monday, May 17, 2021
DTDT Classification:
Infectious Diseases (bacterial)
Infectious Diseases (fungal)
Infectious Diseases (viral)
Diagnostic
Monitoring (Public Health/Counterfeit Detection/Biological)
Quality Control/Quality Assurance
Research Tool
Therapeutic (biologic)
Therapeutic (small molecule)
Antibody
Infectious Diseases (parasitic)
Vaccine
DTDT Description:
Infectious Diseases (bacterial)
Infectious Diseases (fungal)
Infectious Diseases (viral)
Diagnostic
Monitoring (Public Health/Counterfeit Detection/Biological)
Quality Control/Quality Assurance
Research Tool
Therapeutic (biologic)
Therapeutic (small molecule)
Antibody
Infectious Diseases (parasitic)
Vaccine
Collaboration Sought:
Yes
Collaboration Opportunity:
For collaboration opportunities, please contact CDC TTO at tto@cdc.gov or 1-404-639-1330.
Advantages:
- Potentially speed up product development with CDC-developed materials that have already been tested and validated
- Can apply to multiple diagnostic types such as ELISA, immunofluorescent assays, hemagglutination inhibition assays, and more
- Easily adapted to a high-throughput assay for mass screening purposes
-
Application:
Monitoring
(Public Health/Counterfeit Detection/Biological)
Applications:
- Development or refinement of diagnostic assays for coronavirus and other indications
- Controls or a reference reagent source for diagnostic assay validation
- Quality control/quality assurance testing for coronavirus vaccine or therapeutic development
- Monitoring and public health surveillance
- Research tools
NIH Ref. No.:
E-138-2014-0
IC:
CDC
LPM Address:
BG 5601FL RM 2G48 MSC 9804
5601 FISHERS LN
LPM City:
Bethesda
LPM Email:
karen.surabian@nih.gov
LPM Fax:
240-627-3117
Inventor IC:
CDC
CDC
CDC
CDC
CDC
CDC
CDC
Institute or Center:
Lead Inventor:
Disease Area:
